Thursday, April 17, 2008

The great debate

There are not a lot of topics that I get overly emotional about. I'm not heavy into politics. I sometimes feel that I don't have a real opinion on a lot of things. However, there are a couple things I am pretty opinionated about. One is childhood obesity. The other is vaccinations and autism. Childhood obesity will have to wait it's turn for another day.

Myth: Vaccinations cause autism.
Fact: Vaccinations have no correlation with the incidence of autism.
Maybe it's the 8 years of university level science courses I had, but I am definitely one who bases their opinions and decisions on scientific fact. On research. Not on hearsay or personal stories. I'm also skeptical to believe emails or websites sent by groups founded by parents with children of autism. They are not objective. They will find only information that supports their cause. Nor will I believe anything called similar to www.VaccinesKill.com or the like. I have no idea if that's real or not, but you get the idea.

The CDC's official statement:
Many studies have looked at whether there is a relationship between vaccines and autism. The weight of the evidence indicates that vaccines are not associated with autism. But CDC knows that some parents and others may still have concerns about this issue. CDC is committed to protecting the health of children and to identifying the biological and environmental causes of autism and other developmental disabilities, so we will continue to study the role of vaccines.
Also on the CDC website is an article which I will post here. It's a little lengthly, but worth reading. Here is the direct link if you'd like to see references.

Thimerosal and Autism
By Paul A. Offit, MD, Director, Vaccine Education Center, Children’s Hospital of Philadelphia

Some parents are concerned that thimerosal, a mercury-containing preservative contained in the influenza vaccine, causes autism. However, during the past few years a series of biological and epidemiological studies have shown this concern to be unfounded. Here is a summary of the evidence showing that, while some things do cause autism, mercury in vaccines isn’t one of them.

All mercury isn'’t the same:methylmercury vs. ethylmercury

Mercury is a naturally occurring element found in the earth’s crust, air, soil and water. Since the earth’s formation, volcanic eruptions, weathering of rocks and burning of coal have caused mercury to be released into the environment. Once released, certain types of bacteria in the environment can change mercury to methylmercury. Methylmercury makes its way through the food chain in fish, animals, and humans. At high levels, it can be toxic to people. Thimerosal — a preservative still used in the influenza vaccine —contains a different form of mercury called ethylmercury. Studies comparing ethylmercury and methylmercury suggest that they are processed differently in the human body. Ethylmercury is broken down and excreted much more rapidly than methylmercury. Therefore, ethylmercury (the type of mercury in the influenza vaccine) is much less likely than methylmercury (the type of mercury in the environment) to accumulate in the body and cause harm.

Evidence that mercury doesn'’t cause autism

•In 1971 Iraq imported grain that had been fumigated with methylmercury. Farmers ate bread made from this grain. The result was one of the worst, single-source, mercury poisonings in history. Methylmercury in the grain caused the hospitalization of 6,500 Iraqis and killed 450. Pregnant women also ate the bread and delivered babies with epilepsy and mental retardation. But they didn’t deliver babies with an increased risk of autism.•

Four large studies have now compared the risk of autism in children who received vaccines containing thimerosal to those who received vaccines without thimerosal. The studies were consistent, clear and reproducible — the incidence of autism was the same in both groups. Denmark, a country that abandoned thimerosal as a preservative in 1991, actually saw an increase in the disease beginning several years later.

Studies of the head size, speech patterns, vision, coordination and sensation of children poisoned by mercury show that the symptoms of mercury poisoning are clearly different from the symptoms of autism.

Methylmercury is found in low levels in water, infant formula, and breast milk. Although it is clear that large quantities of mercury can damage the nervous system, there is no evidence that the small quantities contained in water, infant formula, and breast milk do. An infant who is exclusively breast-fed will ingest more than twice the quantity of mercury that was ever contained in vaccines and fifteen times the quantity of mercury contained in the influenza vaccine.

What is known about the causes of autism?

•First, like cystic fibrosis or sickle-cell disease, autism clearly has a genetic basis. Researchers found that when one identical twin had autism, the chance that the other twin had autism was about 90 percent; for fraternal twins, the chance was less than 10 percent.

Second, although autism clearly has a genetic basis, environmental factors can also cause the disease. For example, children whose mothers took thalidomide during pregnancy had birth defects, including malformed ears and shortened limbs. But they also had a significantly greater incidence of autism than babies born to mothers who never took thalidomide. Thalidomide clearly caused autism, but only if mothers took it early in pregnancy. If mothers took thalidomide in the second or third trimester of pregnancy, their babies weren’t at increased risk of autism.

•The thalidomide experience showed that there was a vulnerable time early in pregnancy when a drug could possibly cause autism. Echoes of the thalidomide story are found in babies infected with rubella virus. Babies born to mothers who suffered rubella early in their pregnancies develop birth defects involving the eyes, ears, brain, and heart.They also are at greater risk of developing autism, but like thalidomide, only if the baby is exposed to rubella early during pregnancy. Babies don’t develop autism if they are infected with the virus soon after birth.Taken together, these findings suggest that a virus or a drug can cause autism, and that there is a vulnerable time early during pregnancy when the baby is at risk. However, during the second or third trimester of pregnancy, or after the child is born, the window for environmental factors causing autism has apparently closed.

Women in the United States also occasionally received mercury when they were pregnant. It happened when doctors found that the mother’s blood type was not compatible with their baby’s blood type. To prevent this blood mismatch from hurting the baby, mothers were given RhoGam, a product that contained thimerosal as a preservative. However, consistent with the observation in Iraq, babies exposed to thimerosal in RhoGam did not have a greater risk for autism than babies whose mothers never received RhoGam. Although thalidomide and rubella virus can cause autism in pregnancy, scientific evidence clearly indicates that mercury doesn’t.
As a medical professional, especially as a nurse working with infants and concerned parents, this is an issue I face almost daily. Everyone is worried about mercury and vaccines and autism. Rightly so. What parent would knowingly put their child at risk for developmental defects? But I cannot advise parents on skipping vaccinations because of the risk of autism. Firstly, and most importantly, there is NO correlation. It's unfortunate that autism emerges during the same time period that vaccinations are given. But studies have shown that children who received no Thimerosal still had the same incidence of autism as children that did.

Here in Milwaukee we have seen an outbreak of Measles in the past couple weeks. And just the other day we had our first case of Rubella. Last year was the Mumps outbreak. There is no doubt in my mind that these cases are a direct result of unvaccinated children. Diseases like these, which can easily be prevented with an MMR, are potentially fatal for small children with weak immunities. I would gladly give my child a shot that could save them from a completely preventable death.

Some people may subscribe to the theory of "herd immunity," where the immunity of a group as a whole will help to protect the unprotected. But if the trend continues as it does, with less and less immunized members, there will be no more herd immunity.

Spiritually speaking, man has been blessed with the knowledge and ability to create methods by which to protect ourselves from disease. Medical advances have saved countless lives, and vaccines are no exception. Who are we to not take advantage of these blessings? And should adverse effects result, surely they are the intention of a loving Heavenly Father, who knows all, infinitely more than we do.

Still, we are blessed with our own agency, and freedom of choice. We should be educated on all fronts. It just saddens me that children are going unvaccinated because of the slight possibility that an adverse effect may occur. It's like never driving a car because you might get into an accident one day. The odds are small. The benefits far outweigh.

Just my two cents.

7 comments:

Silvs said...

Nice work. This feels like my blog now. Being that I didn't really have much opinion on this before, it's nice to have some ammo. Amy was totally anti-vaccines (or at least she had some relatives that swore they were), and I've always been leery of all the natural remedies and medicine stuff. Thanks for your two cents.

josieposie said...

Karen - the other half of the great debate:

1. Do we know if these kids who have contracted Measles/Rubella here in Milwaukee refused the vaccine because they were afraid of Autism or were they just lazy and didn't keep up on them?

2. True you are a nurse working in the medical profession, but you get your information from other medical professionals, and the CDC, the two outlets that would suffer an immense amount of backlash if a correlation was found. Of course they are going to say there is no known correlation. They don't want to cause bad faith or widespread panic.

3. I have read all the studies you put on your blog - mainly because I have two boys, and Autism is more prevalent in males. I am also a mother, and when it comes to the thought of my child getting Autism it freaks me out. There are treatments/cures for the Measles. There is NOT for autism. I have weighed the risk of both and feel I would rather my kid get Measles than Autism.

4. Ethan received his 1 year immunizations in the middle of September. Not 3 months later he had Diabetes. A disease that does not run in our family at all. The doctors only explanation for getting the disease is that Ethan was born with an auto-immune deficiency and that when his body was presented with a specific virus it switched on the deficiency and started attacking his pancreas. This is their explanation for all auto-immune disease such as Chrones, Lupus, etc. Could Ethan's 1 year immunizations given him diabetes - NO, but they do weaken one's immune system allowing viruses in.

5. If you say it's not the vaccines causing Autism, do you have an explanation as to why it is more and more common now a days? If it is genetic then why aren't they autistic from birth. Why are kids diagnosed at age 2, 4, 8, etc? How do doctors explain the fact that a kid can go from completely normal one day to totally catatonic the next?

Just my two cents.

AnnP said...

I completely agree with you, Karen. One thing that really frightens me is that vaccinations are not 100 percent effective. Because of this, when large numbers of children are not vaccinated, they put MY child at risk, even though she is vaccinated. If more children were vaccinated, then the diseases would have a much harder time spreading, leaving my child safer even though the vaccine is not completely effective.

In response to josieposie and her point number three, yes, there are treatments for Measels, etc. However, these are still very dangerous diseases. The reason these vaccines were created was because of the high mortality rate of children when they contracted these diseases. There are treatments for them, but children, especially young children, can die from them. I would rather have my child have autism, and still be part of my life, then have them die at a very young age - especially when I could have done something to save them.

In response to josieposie's fith point, I feel that doctor's have more knowledge about Autism now that they didn't have even 15 years ago. Because of this, they are able to diagnose Autism more now then they could in the past. I am not saying that this is the only reason for the increase in Autism, but I do feel that it is part of it.

Karen, I feel this is going to garner some very heated responses. I think that many parents have considered this when it is time to start giving vaccinations. We all come to some decision and then feel very strongly about it, and the reasons why.

Anonymous said...

I have some concerns about vaccine safety, but please don't call me "anti-vaccine." Meryl Streep isn't "anti-apple."

My friend's child has vaccine-strain measles in lesions lining his intestinal mucosa, as per biopsies.

Another's daughter died after a seizure following vaccination; her doctor diagnosed mitochondrial disorder. Similar to the Poling case conceded in November by scientists at DHHS (not the vaccine court).

Other friends have children with mercury that didn't show up in blood tests until chelating with meso-2,3-dimercaptosuccinic acid. Still others have videos and baby books showing regressive autism after vaccination.

These parents don't want to stop the vaccination program. They do want funding to find out WHY some children are being paradoxically injured by vaccines. They feel their children deserve medical treatment instead of denial, and being written off as collateral damage in the war on disease.

You can quote the CDC and Paul Offit all you want -- it's quick, it's easy -- but do not believe they are unbiased and 100% altruistic. And consider what a Wayne State toxicologist said recently, that relying on epidemiology is like "doing surgery with a dull knife."

The 2005 Burbacher NIEHS primate study showed that ethylmercury leaves the bloodstream quickly... because it binds quickly to brain tissue.

Parran et al. showed that Thimerosal damages cells at concentrations as low as 0.5 parts per BILLION. More than 90% of 2007-08 flu shots contained 50,000 ppb.

You would not believe what parents are finding in documents obtained under the Freedom Of Information Act (FOIA).

It's sad that it has to take 4,800 legal cases in the Federal Autism Omnibus Proceedings before the CDC starts waking up to parent reports of vaccine injury.

This issue cannot be summed up in bullet points and tacit assurances. Check out "Fighting the Autism-Vaccine War" by Dr. Bernadine Healy, M.D., Health Editor for U.S. News & World Report. She's also:
- Former director, National Institutes of Health
- Member, President's Council of Advisers on Science &Technology
- Former president & CEO, American Red Cross
http://health.usnews.com/articles/health/brain-and-behavior/2008/04/10/fighting-the-autism-vaccine-war.html

Then read Dr. Jon Poling's article in the Atlanta Journal Constitution. Dr. Poling is a practicing neurologist in Athens and clinical assistant professor at the Medical College of Georgia. His wife Terry is an ICU nurse and attorney.
http://www.ajc.com/opinion/content/opinion/stories/2008/04/11/polinged0411.html

The issue is safer vaccines and healthier kids. Unfortunately that means acknowledging some inconvenient and unpleasant realities.

amy said...

whoa, who's 'anonymous'?! anyways, for me, i'm just glad i didn't know much about this stuff when it came to vaccinating my kids. ignorance can be bliss!

Unknown said...

Two article to explain the increase in diagnosis:


Is There Really an Autism Epidemic?

Fact: Autism rates have been going up. Recent years have seen a higher percentage of kids getting diagnosed with autism. The trend seems to have begun in the 1980s and to have picked up speed in the 1990s.

Eric Fombonne, MD, FRCPsych, of the Institute of Psychiatry at King's College, London, has studied autism in the U.K.

"From our data, we can say that we have a prevalence that is 62 cases per 10,000 children," he told WebMD in a 2001 interview. "In the mid-1960s, we showed rates of 4 cases per 10,000."

Isn't this the sign of an epidemic? Not necessarily.

"You cannot compare studies now to studies from 30 years ago," Fombonne said. "It would be comparing oranges not with apples, but with sheep."

Children with autism vary widely. It was not until 1940 that this constellation of problems with social interaction, communication, and focused interest came to be called autism. And it was not until 1980 that the diagnosis of autism was formalized.
In 1994, the diagnosis changed again. Kids diagnosed with autism from 1980 through 1993 had to meet six mandatory criteria. The new 1994 definition offered 16 optional criteria, only eight of which had to be met. Gernsbacher says the 1994 diagnosis made it much easier for a child to be labeled autistic.

The federal Individuals with Disabilities Education Act, passed in 1991, assures appropriate public education for children with autism. Soon after, schools began reporting high numbers of students with autism. Those numbers keep going up. But that doesn't mean there's an autism epidemic, Gernsbacher says, any more than increased sales of petite clothing means women are getting smaller.

"My hunch is that if we looked at the production and purchase of petite-sized clothing we'd see a greatly increasing trend in the number of petite-sized garments produced and purchased over the past two decades," she says. "Should we therefore conclude that U.S. women are getting increasingly more petite? Probably not. There was probably always a contingent of petite-sized women, and their needs are being increasingly better met."

Gernsbacher points to data from Fombonne and others suggesting that there are 5.8 to 6.7 autism cases among every 1,000 U.S. children. If that's so, we haven't found them all yet. Even Oregon, which led the nation with 4.3 autism cases per 1,000 children in 2002-2003, still has a way to go. Other states lag much farther behind.


Study: Childhood Rise in Autism Cases Real
But Reason for the Increase Remains Unexplained
By Salynn Boyles
WebMD Medical News

March 7, 2005 - Since the 1990s, there's been a dramatic increase in autismautism among school-age children.

The data are from the U.S. Department of Education, and the report hints that the increases seen with time are real.

Research has suggested that the rise in autism could be largely explained by changes in diagnosis, with children who might have been classified as mentally retarded or speech impaired before the 1990s now being classified as autistic.

Now back to me:

Also, lots of things that are genetic don't show up right at birth. Um...can you say cancer? Alzheimer's? Muscular dystrophy? Cystic fibrosis? As the body grows and develops it hits milestones when disease is more likely to occur.

Also, who's to say an increase in environmental factors haven't played a part in the increase in diagnosis? The increase in processed foods, poor air quality, and other environmental factors combined are sure to play a part in the increase in morbidity and mortality overall.

I also feel the fact that I am not a mother YET has no bearing whatsoever as to my stance.

Lastly, there is NO treatment for measles. Just methods to lessen the symptoms. There are no cures for a dead child.

Antony said...

It may well be that there is no correlation between mercury and autism, but here's the problem I have:
Mercury is not needed for the vaccine. It's just a preservative. Rather than studying up on the subject, believe someone else, or just risk it, I think I'll just find a vaccine that contains some other form of preservative (they do exist).